The Radiomics workflow basically consists the following steps (Figure 3). The first step is acquisition of high quality standardized imaging, for diagnostic or planning purposes. The macroscopic tumor is defined on these images, either with an automated segmentation method or alternatively by an experienced radiologist or radiation oncologist. Next, a large number of quantitative features is extracted from the previously defined tumor region. These features describe, amongst others, tumor image intensity, texture and shape and size of the tumor. The final step is analysis of the acquired imaging features.

Figure 1: Different sources of information, e.g. demographics, imaging, pathology, toxicity, biomarkers, genomics and proteomics, can be used for selecting the optimal treatment.

Figure 2: Typical examples of lung tumors, showing differences captured by simple CT imaging.. Displayed regions are 16x16 cm for the displayed CT slices and 16x16x16 cm for the 3D renderings

Figure 3: Schematic representation of the workflow